Cayo Santa María (Cay or "Key" of Santa Maria) is an island off Cuba's north central coast in the Jardines del Rey archipelago. The island is linked by road and bridge to the town of Caibarién on the main island. Cayo Santa María is well known for its white sand beaches and luxury all-inclusive resorts.
The island is linked to the mainland near Caibarién by a 48 km causeway constructed between 1989 and 1999 by Campaña de Las Villas. The island is administered as part of Caibarién, a municipality of Villa Clara Province.